Washington, DC - Aided by a high-powered brain scanner and a 3D printer, NIH researchers peered inside the brains of hundreds of multiple sclerosis patients and found that dark rimmed spots representing ongoing, “smoldering” inflammation, called chronic active lesions, may be a hallmark of more aggressive and disabling forms of the disease.

Dallas, Texas - Non-invasive techniques and devices for assessing blood flow and other diagnostic considerations for people with critical limb ischemia are addressed in a new scientific statement from the American Heart Association, published in the Association’s flagship journal Circulation.

Washington, DC - Though food allergy affects more than 4.8 million children in the United States, no approved preventative treatments currently exist. While experimental desensitization strategies are available in research settings, people with food allergies must avoid known allergens and are advised to carry injectable epinephrine to prevent potentially life-threatening allergic reactions caused by  accidental exposures. To help alleviate this risk, a new study to evaluate an experimental treatment for food allergy launched today. The study is supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health; Genentech, a member of the Roche Group; and Novartis Pharmaceuticals Corporation.

Boston, Massachusetts - Measuring a menopausal woman’s pulse wave at her wrist may help explain the increase in cardiovascular disease risk during menopause better than a standard blood pressure measurement, according to preliminary research presented at the American Heart Association’s Basic Cardiovascular Sciences 2019 Scientific Sessions.

Washington, DC - Researchers have found that anti-inflammatory biologic therapies used to treat moderate to severe psoriasis can significantly reduce coronary inflammation in patients with the chronic skin condition. Scientists said the findings are particularly notable because of the use of a novel imaging biomarker, the perivascular fat attenuation index (FAI), that was able to measure the effect of the therapy in reducing the inflammation.

Washington, DC - A large-scale, collaborative, systems biology approach is needed to expedite the discovery of treatments for dry age-related macular degeneration (AMD) – a leading cause of blindness among people 65 and older for which is there is no treatment— according to a report by a working group of scientists appointed by the National Advisory Eye Council (NAEC). The NAEC is a 12-member panel that guides the National Eye Institute (NEI), part of the National Institutes of Health. The NAEC charged the working group to assess the state of research on dry AMD and to propose directions for future research.