Washington, DC - Monday, the U.S. Food and Drug Administration approved Uptravi (selexipag) tablets to treat adults with pulmonary arterial hypertension (PAH), a chronic, progressive, and debilitating rare lung disease that can lead to death or the need for transplantation.

Washington, DC - A study of mice shows how proteasomes, a cell’s waste disposal system, may break down during Alzheimer’s disease, creating a cycle in which increased levels of damaged proteins become toxic, clog proteasomes, and kill neurons. The study, published in Nature Medicine and supported by the National Institutes of Health, suggests that enhancing proteasome activity with drugs during the early stages of Alzheimer’s may prevent dementia and reduce damage to the brain.

Dallas, Texas - Molecular biologists at UT Southwestern Medical Center have identified a gene called NORAD that helps maintain the proper number of chromosomes in cells, and that when inactivated, causes the number of chromosomes in a cell to become unstable, a key feature of cancer cells.

Rochester, Minnesota - The Centers for Disease Control and Prevention says the United States is in the midst of a drug-overdose epidemic. In their Morbidity and Mortality Weekly Report (MMWR), the CDC reports that last year overdose killed more than 45,000 people, most of whom had taken opioids - heroin or prescription medications such as oxycodone. They also report that since 2000, the death rate from overdoses involving opioid pain relievers and heroin increased 200 percent.

Dallas, Texas - A liver hormone works via the brain’s reward pathway to reduce cravings for sweets and alcohol in mammals, UT Southwestern Medical Center researchers have found.

Scottsdale, Arizona - Holiday travel is expected to soar this season. AAA expects more than 100 million Americans to hit the highways and the skyways. While a majority of travelers will drive, nearly 6 million people are expected to fly to their holiday destination.